Recently, in the fields of daily chemical care, medical hygiene, and personal care products, Polyquaternium-37 Powder—a cationic polymer with high-efficiency conditioning, long-lasting moisturizing, and mild antibacterial properties—has continued to be a "core functional raw material" in formula development across various sectors, thanks to its excellent film-forming ability, compatibility, and biosafety. As an important member of the polyquaternium family, Polyquaternium-37 Powder not only breaks the limitations of traditional conditioners such as "single function and poor adaptability" but also, with its characteristics of "high activity, low irritation, and easy compounding", plays an irreplaceable role in diverse scenarios ranging from shampoos and conditioners to body washes and medical wet wipes. It has become a key ingredient driving the development of daily chemical products toward the direction of "mild, efficient, and multi-functional integration".
In terms of the product's essence, Polyquaternium-37 is a synthetic cationic high-molecular polymer. Its core chemical structure is prepared through free radical polymerization using monomers such as acrylamide and dimethyldiallylammonium chloride. The molecular chain is rich in a large number of cationic groups (e.g., quaternary ammonium groups). This structure endows it with strong hydrophilicity and surface activity, enabling it to quickly bind to the negatively charged surfaces of skin and hair. Polyquaternium-37 Powder is a white to off-white fine powder produced through special drying processes (e.g., spray drying). It has no obvious odor, is easily soluble in polar solvents such as water and ethanol, and maintains good stability over a wide pH range (pH 3.0-9.0), with low susceptibility to hydrolysis or degradation. Moreover, it exhibits excellent compatibility with most daily chemical raw materials (e.g., surfactants, moisturizers, plant extracts) and does not cause issues such as stratification or precipitation.
In terms of purity and safety, high-quality Polyquaternium-37 Powder has a purity of over 98% and residual monomer content below 0.1%, effectively avoiding skin and mucous membrane irritation caused by harmful substances. Evaluated by authoritative institutions such as the European Union's Cosmetic Ingredient Database (CosIng) and the U.S. Cosmetic Ingredient Review (CIR), Polyquaternium-37 is classified as a low-toxicity and low-sensitization ingredient. When used in compliance with regulations, it poses no health risks to the human body, and can be safely used even on sensitive skin and infant skin. After years of scientific research and market verification, relying on its core advantages of "high-efficiency conditioning, long-lasting moisturizing, mild antibacterial activity, and easy film-forming", Polyquaternium-37 Powder has demonstrated outstanding efficacy in four major fields—hair care, skin care, medical hygiene, and oral care—becoming a "multi-functional tool" in the daily chemical and pharmaceutical industries.
In hair care products (e.g., shampoos, conditioners, hair masks, serums), Polyquaternium-37 Powder is a "star conditioning ingredient". Its cationic groups can quickly adsorb onto the negatively charged surface of hair strands, forming a uniform and thin cationic film that achieves the three-in-one effects of "repair, smoothing, and antistatic". For damaged hair (e.g., dry and frizzy hair after perming or dyeing), this film fills the gaps between hair cuticles, reduces friction between hair strands, lowers the risk of breakage during combing, and locks in moisture inside the hair to improve dryness and frizz. For healthy hair, it forms a protective layer on the hair surface to resist damage from external factors (e.g., ultraviolet rays, pollutants), maintaining the smoothness and luster of the hair. In addition, Polyquaternium-37 has excellent antistatic properties, which can neutralize the negative charges on the hair surface, preventing hair tangling and flyaways caused by static electricity—making it particularly suitable for use in dry seasons. Clinical tests show that conditioners containing 0.5%-2% Polyquaternium-37 Powder can reduce hair combing resistance by 40%-50%, increase hair smoothness by more than 35%, and maintain these effects for over 24 hours.
In skin care products (e.g., body washes, body lotions, moisturizing creams, hydrating serums), Polyquaternium-37 Powder exhibits excellent moisturizing and barrier repair effects due to its cationic properties and film-forming ability. The cationic groups on its molecular chain can bind to the negatively charged corneocytes on the skin surface, forming a breathable moisturizing film. This film not only reduces skin moisture evaporation (decreasing transepidermal water loss by 25%-30%) but also allows the skin to breathe normally, avoiding the greasiness associated with traditional moisturizers. At the same time, this moisturizing film can block the invasion of external pollutants and dust into the skin, assisting in repairing damaged skin barriers. For people with dry or sensitive skin, body lotions containing Polyquaternium-37 can effectively alleviate skin dryness and flaking, improving skin hydration. Adding low-concentration (0.1%-0.5%) Polyquaternium-37 Powder to body washes can also reduce skin irritation caused by surfactants, preventing skin tightness after bathing and keeping the skin moist and smooth. Furthermore, its mildness makes it an ideal raw material for infant skin care products, and some infant body washes and lotions have already adopted this ingredient to provide gentle care for babies' delicate skin.
In medical hygiene products (e.g., medical wet wipes, disinfectant gels, wound care dressings), Polyquaternium-37 Powder serves as an important functional ingredient due to its cationic antibacterial properties and biocompatibility. Its cationic groups can disrupt the integrity of bacterial cell membranes, exerting a significant inhibitory effect on common pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, and Candida albicans (with an antibacterial rate of over 90%). The antibacterial effect is long-lasting, continuing to inhibit bacterial growth after product use. In medical wet wipes, Polyquaternium-37 not only enhances the cleaning ability of the wipes but also reduces the risk of cross-infection through its antibacterial action, making it particularly suitable for use in scenarios such as hospitals and nursing homes. In wound care dressings, it can act as an auxiliary antibacterial ingredient, working synergistically with other antibacterial agents (e.g., silver ions) to enhance the antibacterial effect of the dressing. Meanwhile, its film-forming property protects the wound from external contamination and promotes wound healing. Compared with traditional antibacterial agents (e.g., chlorhexidine, benzalkonium chloride), Polyquaternium-37 has lower irritation to skin and mucous membranes, does not cause skin allergies or dryness, and offers higher safety.
In oral care products (e.g., toothpaste, mouthwash), Polyquaternium-37 Powder also demonstrates unique application value. Its cationic groups can adsorb onto the tooth surface and gingival mucosa, forming a protective film. This film not only reduces the adhesion and growth of dental plaque (decreasing plaque by approximately 30%) but also alleviates the erosion of tooth enamel by acidic substances produced by oral bacteria, assisting in the prevention of dental caries. Additionally, this ingredient can reduce the irritation of toothpaste abrasives to the gums, lowering the risk of gingival bleeding during brushing—making it particularly suitable for people with sensitive gums. When used in mouthwash, Polyquaternium-37 can work synergistically with fluoride to increase the adhesion rate of fluoride on the tooth surface, enhancing the anti-caries effect. At the same time, its mildness avoids the spicy sensation of traditional mouthwashes, improving user comfort. Currently, some high-end toothpaste brands have added it as a functional ingredient to provide consumers with more comprehensive oral care solutions.
Polyquaternium-37 are now available for purchase at Xi’an Biof -Technology Co., Ltd. For more information , visit https://www.biofingredients.com.
XI'AN BIOF BIO-TECHNOLOGY CO.,LTD
Email: Tom@xabiof.com
Tel/WhatsApp: +86-15091533695
Website: https://www.biofingredients.com
Post time: Oct-29-2025
